Conductometric Titration Method for Determination of Alfuzosin Hydrochloride and Fexofenadine Hydrochloride Using Sodium Tetraphenylborate

A simple, precise and low cost conductometric method for the determination of alfuzosin hydrochloride and fexofenadine hydrochloride in pure form and pharmaceutical formulations using sodium tetraphenylborate has been described. The method is based on the formation of ion association complex of cations coming from the cited drugs with tetraphenylborate anions and the conductance of the solution is measured as a function of the volume of titrant. Various experimental conditions were evaluated. The described procedures allowed the determination of the studied drugs in double distilled water in the range of 2.13 – 10.65 and 2.50 – 13.45 mg of alfuzosin hydrochloride and fexofenadine hydrochloride, respectively. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method is indicated by the excellent recovery 99.85-102.49 and 99.80-100.48% for alfuzosin hydrochloride and fexofenadine hydrochloride, respectively, and the precision is supported by the low relative standard deviation < 3.04%. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to potentiometric pharmacopoeial methods.